3,924 research outputs found

    PCN25 COST-EFFECTIVENESS ANALYSIS OF ERLOTINIB VERSUS DOCETAXEL AS A SECOND- OR THIRD-LINE TREATMENT OF NON-SMALL CELL LUNG CANCER IN KOREA

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    Customer Satisfaction with and Loyalty towards Online Travel Products: A Transaction Cost Economics Perspective

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    This study examines the usefulness of the theory of transaction cost economics (TCE) for the online travel market and investigates customer satisfaction and loyalty with the transaction cost over the Internet taken into account. Using structural equation modelling (SEM), the authors identify the relationships among the antecedents (uncertainty, personal security and buying frequency), the mediating variable (transaction costs) and endogenous constructs (customer satisfaction and loyalty). The findings suggest that the satisfaction and loyalty of customers purchasing travel products over the Internet are affected negatively by transaction costs, which are determined by uncertainty, personal security and buying frequency. Moreover, a significantly negative relationship is identified between buying frequency and customer satisfaction

    Withdrawal Note: Expression of Ski in the Follicles of eCG-primed Immature Hypophysectomized Rat Ovary

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    Hybrid desalination processes for beneficial use of reverse osmosis brine: Current status and future prospects

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    © 2018 Elsevier B.V. As water shortage has increasingly become a serious global problem, desalination using seawater reverse osmosis (SWRO) is considered as a sustainable source of potable water sources. However, a major issue on the SWRO desalination plant is the generation of brine that has potential adverse impact due to its high salt concentration. Accordingly, it is necessary to develop technologies that allow environmentally friendly and economically viable management of SWRO brines. This paper gives an overview of recent research works and technologies to treat SWRO brines for its beneficial use. The treatment processes have been classified into two different groups according to their final purpose: 1) technologies for producing fresh water and 2) technologies for recovering energy. Topics in this paper includes membrane distillation (MD), forward osmosis (FO), pressure-retarded osmosis (PRO), reverse electrodialysis (RED) as emerging tools for beneficial use of SWRO brine. In addition, a new approach to simultaneously recover water and energy from SWRO brine is introduced as a case study to provide insight into improving the sustainability of seawater desalination

    Effects of a deformable striking ship's bow on the structural crashworthiness in ship–ship collisions

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    Ship–ship collision accidents continue to occur regardless of the continuous efforts to prevent them, and they essentially involve highly nonlinear problems associated with structural crashworthiness due to crushing and fracture. The nonlinear finite-element method is one of the most powerful techniques to solve the problems. In industry practice, the bow structure of a striking ship is often modelled as a rigid body as it is usually much stiffer than the side structure of a struck ship. However, reality is that the initial kinetic energy in a ship–ship collision accident can be absorbed by the damages of not only the struck ship's side structures but also the striking ship's bow structures because the striking ship bow structure is actually deformable. The aim of the present study is to examine the effects of a deformable striking ship's bow on the structural crashworthiness in ship–ship collisions. In the present study, two scenarios are considered where the side structure of a VLCC class double hull oil tanker is collided by the bow structure of a VLCC class double hull oil tanker or a SUEZMAX class double hull oil tanker. All of the ships considered are real ships in operation. The structural crashworthiness in terms of the collision force–penetration relation and the collision energy–penetration relation is then studied with two cases in which the striking ship's bow structures are either rigid or deformable. It is concluded that the striking ship's bow may be modelled as a rigid body in minor collisions at a collision angle of about 90° where the initial kinetic energy is entirely consumed before the inner hull structure is ruptured, but it should be modelled as a deformable body in a major collision accident or at an inclined collision angle where the maximum penetration can be greater than the double side breadth

    High Fidelity Tape Transfer Printing Based On Chemically Induced Adhesive Strength Modulation

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    Transfer printing, a two-step process (i.e. picking up and printing) for heterogeneous integration, has been widely exploited for the fabrication of functional electronics system. To ensure a reliable process, strong adhesion for picking up and weak or no adhesion for printing are required. However, it is challenging to meet the requirements of switchable stamp adhesion. Here we introduce a simple, high fidelity process, namely tape transfer printing(TTP), enabled by chemically induced dramatic modulation in tape adhesive strength. We describe the working mechanism of the adhesion modulation that governs this process and demonstrate the method by high fidelity tape transfer printing several types of materials and devices, including Si pellets arrays, photodetector arrays, and electromyography (EMG) sensors, from their preparation substrates to various alien substrates. High fidelity tape transfer printing of components onto curvilinear surfaces is also illustrated

    Chasing Carbon: The Elusive Environmental Footprint of Computing

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    Given recent algorithm, software, and hardware innovation, computing has enabled a plethora of new applications. As computing becomes increasingly ubiquitous, however, so does its environmental impact. This paper brings the issue to the attention of computer-systems researchers. Our analysis, built on industry-reported characterization, quantifies the environmental effects of computing in terms of carbon emissions. Broadly, carbon emissions have two sources: operational energy consumption, and hardware manufacturing and infrastructure. Although carbon emissions from the former are decreasing thanks to algorithmic, software, and hardware innovations that boost performance and power efficiency, the overall carbon footprint of computer systems continues to grow. This work quantifies the carbon output of computer systems to show that most emissions related to modern mobile and data-center equipment come from hardware manufacturing and infrastructure. We therefore outline future directions for minimizing the environmental impact of computing systems

    Novel membrane bioreactor (MBR) coupled with a nonwoven fabric filter for household wastewater treatment

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    Conventional and modified membrane bioreactors (MBRs) are increasingly used in small-scale wastewater treatment. However, their widespread applications are hindered by their relatively high cost and operational complexity. In this study, we investigate a new concept of wastewater treatment using a nonwoven fabric filter bag (NFFB) as the membrane bioreactor. Activated sludge is charged in the nonwoven fabric filter bag and membrane filtration via the fabric is achieved under gravity flow without a suction pump. This study found that the biofilm layer formed inside the NFFB achieved 10 mg/L of suspended solids in the permeate within 20 min of initial operation. The dynamic biofilter layer showed good filterability and the specific membrane resistance consisted of 0.3-1.9 × 1012 m/kg. Due to the low F/M ratio (0.04-0.10 kg BOD5/m3/d) and the resultant low sludge yield, the reactor was operated without forming excess sludge. Although the reactor provided aerobic conditions, denitrification occurred in the biofilm layer to recover the alkalinity, thereby eliminating the need to supplement the alkalinity. This study indicates that the NFFB system provides a high potential of effective wastewater treatment with simple operation at reduced cost, and hence offer an attractive solution for widespread use in rural and sparsely populated areas. Crown Copyright © 2009

    A practical method to determine the dynamic fracture strain for the nonlinear finite element analysis of structural crashworthiness in ship–ship collisions

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    Ship–ship collisions continue to occur regardless of efforts to prevent them. The collisions involve highly nonlinear characteristics associated with structural crashworthiness, including crushing and fracture as well as buckling and plastic collapse. When applying nonlinear finite element analysis (NLFEA) to solve these problems, a reliable critical fracture strain accounting for strain-rate effects due to collision speed must be implemented. This study proposes a practical method to estimate the dynamic fracture strain to be used for the structural crashworthiness analysis associated with the collisions. For this purpose, the strain-rate characteristics in struck ship were investigated by NLFEA, in which the striking vessel was assigned various velocities in the range of practical ship speeds. Based on computations, an empirical formula was developed to calculate the strain rate at a given collision speed, allowing for a practical estimation of the dynamic fracture strain. The formula is validated by a comparison with experiment

    Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

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    © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. To investigate protective effects and molecular mechanisms of green tea polyphenols (GTP) on nonalcoholic fatty liver disease (NAFLD) in Zucker fatty (ZF) rats. METHODS Male ZF rats were fed a high-fat diet (HFD) for 2 wk then treated with GTP (200 mg/kg) or saline (5 mL/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC), and sterol regulatory element-binding protein 1c (SREBP1c). RESULTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFLD. GTP intervention decreased weight gain (10.1%, P = 0.052) and significantly lowered visceral fat (31.0%, P < 0.01). Compared with ZF-controls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum ALT and AST levels (both P < 0.01) were observed in GTP-treated ZF rats. GTP treatment also attenuated the elevated TNFα and IL-6 in the circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172 (P < 0.05) and phosphorylated ACC and SREBP1c (both P < 0.05), indicating diminished hepatic lipogenesis and triglycerides out flux from liver in GTP treated rats. CONCLUSION The protective effects of GTP against HFD-induced NAFLD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway
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